Peanut Allergy Treatment, known as Palforzia in UK & USA

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Peanut Allergy Treatment, known as Palforzia in UK & USA

Peanut Allergy Treatment, known as Palforzia in UK & USA :

Thousands of children and young people will receive a pioneering treatment for peanut allergy after NHS England secured the first deal of its kind in Europe.

The treatment, known as Palforzia, helps to reduce the severity of reactions to peanuts – including anaphylaxis – making family holidays abroad, birthday parties, and Christmas treats possible for some children for the first time.

Peanut Allergy Treatment, known as Palforzia in UK & USA

Patients receive a monthly dose, enabling tolerance to be carefully built over time.

Children and young people in England will be the first in Europe to benefit from the treatment through an access deal struck by the NHS.

Up to 600 aged four to 17 are expected to be treated this year, rising to as many as 2,000 each year after that.

Peanut allergy affects one in 50 children in the UK, and is one of the most common causes of food-related deaths.

Currently, people with the allergy have to strictly avoid peanuts and manage any allergic reactions with emergency medication.

what is peanut allergy ?

A peanut allergy is a reaction that occurs when your body mistakenly identifies peanuts as harmful substances. When you eat peanuts or food containing peanuts, your immune system —the body’s natural defense system that fights infections and diseases—overreacts and can cause a serious, even life-threatening response.

Combination peanut allergy treatment leads to fewer side effects

What are Peanut allergy signs and symptoms? , which can include:

  • Skin reactions, such as hives, redness or swelling.
  • Itching or tingling in or around the mouth and throat.
  • Digestive problems, such as diarrhea, stomach cramps, nausea or vomiting.
  • Tightening of the throat.
  • Shortness of breath or wheezing.
  • Runny nose

 

Dangerous Allergies: Anaphylaxis and Life-Threatening Allergy Triggers
What are Peanut allergy signs and symptoms? , which can include:

Professor Stephen Powis, NHS medical director, said: “This pioneering treatment can be life-changing for patients and their families and, thanks to the deal the NHS has struck, people here will be the first in Europe to benefit.

“It will reduce the fear and anxiety for patients and their families who may have been living with this allergy for years, and carrying around emergency medication just in case.

“They should be able to able to enjoy meals out or holidays abroad together without worrying about an allergic reaction that could land them in hospital or worse.

“This first in Europe patient access deal is just one of a series of commercial agreements the NHS has secured for innovative treatments for patients over the past 18 months, while also treating thousands of people with Covid-19 as well as delivering the biggest and most successful vaccination programme in health history”.

Peanut allergy: New hope for sufferers as 'first of its kind' treatment  unveiled in UK

Manufactured by Aimmune Therapeutics, Palforzia is an oral treatment that aims to provide children with a severe allergy with some tolerance to peanut protein so that a serious, or fatal, reaction through accidental exposure can be averted.

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Evelina London Children’s Hospital has taken part in two large peanut allergy trials, PALISADE and ARTEMIS.

The ARTEMIS study, one of the largest peanut allergy trials ever conducted, found approximately six in 10 four- to 17-year-olds who reacted to around 10mg of peanut protein at the start of the trial were able to take a dose of 1,000mg of peanut protein by the end, which is equivalent of three to four peanut kernels – well beyond the amount typically involved in an accidental exposure.

For nine-year-old Emily, from London, being part of the PALISADE trial means she has been able to eat birthday cake, go on her first holiday abroad, and even feed animals at the zoo.

Sophie Pratt, Emily’s mother, said: “Being on the clinical trial has changed our whole family’s lives.

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“The treatment we received has meant that Emily is free from limits and the fear that the tiniest mistake could put her life at risk, and it has removed all the tension and worry that the simple act of eating loomed over us every day.

“It was particularly noticeable at special occasions like birthdays, Christmas and on holidays where there are often special foods like cakes, ice cream and treats that invariably had warnings ‘may contain peanuts’ or menus not in English.

“Since the trial Emily can go to parties and playdates with confidence, eat in restaurants without us having to call ahead to check the menu, and we’ve managed to have her first holiday abroad to New York and even taken part in feeding animals at zoo experiences – which is Emily’s passion.

“We could not be more grateful”.

Professor George du Toit, children’s allergy consultant at Evelina London, has been Senior Investigator for the UK in both the ARTEMIS and PALISADE trials. He said: “This is great news for children and young people with peanut allergies.

“The approval of Palforzia represents a significant step forward towards improving the care for allergy sufferers, and we will now have access to the first treatment licensed to reduce the severity of this allergy and to protect against accidental exposure to peanuts.

“This will make a huge impact to the everyday lives of our patients and their families”.

NICE will publish its final guidance on Palforzia early next year, allowing the treatment to be accessed by young people with a peanut allergy.

The Palforzia deal is one of a series of medicine deals made possible by the NHS’ advanced commercial capabilities, which have also secured patient access to cutting-edge one-shot gene therapies like life-saving drug Zolgensma, which can help babies with Spinal Muscular Atrophy move and walk; and the first new treatment for sickle cell disease in more than two decades.

source: https://www.england.nhs.uk/

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